Sign Out
Acute ST-elevation myocardial infarction
Adult: Initially, 30 mg (3,000 u) via IV w/ 1 mg/kg (100 u/kg) via SC given at the same time. Dose should be followed by 1 mg/kg (100 u/kg) via SC 12 hrly for 8 days or until hospital discharge. The 1st 2 SC doses should not exceed 100 mg (10,000 u) each. Patients who undergo PCI: An additional 300 mcg/kg (30 u/kg) via IV given at the time of the procedure if the last SC dose was given >8 hr ago.
Elderly: ≥75 yr SC: 750 mcg/kg (75 u/kg) 12 hrly, w/ max 75 mg (7500 u) for each of the 1st 2 doses.
Elderly: ≥75 yr SC: 750 mcg/kg (75 u/kg) 12 hrly, w/ max 75 mg (7500 u) for each of the 1st 2 doses.
Subcutaneous
Unstable angina
Adult: 1 mg/kg (100 u/kg) 12 hrly for 2-8 days.
Subcutaneous
Prophylaxis of venous thromboembolism during surgical procedures
Adult: Low to moderate risk: 20 mg (2,000 u) once daily for 7-10 days or until the risk of thromboembolism has diminished, w/ the 1st dose approx 2 hr pre-op. High risk: 40 mg (4,000 u) once daily w/ 1st dose approx 12 hr pre-op. Alternatively, 30 mg (3,000 u) bid starting w/in 12-24 hr post-op. Continue treatment at 40 mg (4,000 u) once daily for a further 3 wk after hip replacement surgery. Immobilised patients: 40 mg (4,000 u) once daily for at least 6 days, continue treatment until patient becomes fully ambulant, up to max of 14 days.
Child: <2 mth 750 mcg/kg (75 u/kg) 12 hrly; ≥2 mth 500 mcg/kg (50 u/kg) 12 hrly.
Child: <2 mth 750 mcg/kg (75 u/kg) 12 hrly; ≥2 mth 500 mcg/kg (50 u/kg) 12 hrly.
Subcutaneous
Deep vein thrombosis
Adult: 1 mg/kg (100 u/kg) 12 hrly or 1.5 mg/kg (150 u/kg) once daily for at least 5 days and until oral anticoagulants is established.
Child: <2 mth 1.5 mg/kg (150 u/kg) 12 hrly; ≥2 mth 1 mg/kg (100 u/kg) 12 hrly.
Child: <2 mth 1.5 mg/kg (150 u/kg) 12 hrly; ≥2 mth 1 mg/kg (100 u/kg) 12 hrly.
Subcutaneous
Prophylaxis of clotting in the extracorporeal circulation during haemodialysis
Adult: 1 mg/kg (100 u/kg) into the arterial line of the circuit at the start of the dialysis session. Give a further 0.5-1 mg/kg (50-100 u/kg) dose if required. Reduce dose at high risk of haemorrhage patients.
